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Tris(hydroxymethyl)aminomethane (TRIS, Trometamol) 99.0-100.5% USP, Ph. Eur.

Supplier: VWR Chemicals

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87020.290EA 0 INR InStock
87020.290 87020.360 87020.460
Tris(hydroxymethyl)aminomethane (TRIS, Trometamol) 99.0-100.5% USP, Ph. Eur.
Tris(hydroxymethyl)aminomethane (TRIS, Trometamol)
Appearance: White or almost white, crystalline powder or colourless crystals.
Residues of metal catalysts or reagents: Conforms to EMEA/CHMP/SWP/4446/2000

Caution: Not for use as Active Pharmaceutical Ingredient (API)


Formula: NH₂C(CH₂OH)₃
MW: 121.14 g/mol
Boiling Pt: 357
Melting Pt: 169…172 °C
Density: 1.328 g/cm³ (20 °C)
Storage Temperature: Ambient
 MDL Number: MFCD00004679
CAS Number: 77-86-1
EINECS: 201-064-4
Merck Index: 13,09842
https://qa.digitalassets.avantorsciences.com/adaptivemedia/rendition?id=11a03d1ab6b2c11b9a2c83f0a73fc4264cec0110&vid=b84ca1743f9dfe50eb47c249460ab41a6772ceb2&prid=web&clid=SAPDAM
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Specification Test Results
Appearance Conforms (see CoA/CoS)
Heavy metals (as Pb) Max. 10 ppm
Residual solvents Class 2 (ICH Q3C) : Passes test USP
Methanol Below option 1 limit
Other residual solvents(Ph.Eur./ICH) Unlikely by manuf.process
Residues of metal catalysts or reagents Unlikely by manuf.process
As (Arsenic) Max. 2 ppm
Cd (Cadmium) Max. 1 ppm
Co (Cobalt) Max. 1 ppm
Hg (Mercury) Max. 2 ppm
Ni (Nickel) Max. 50 ppm
Pb (Lead) Max. 3 ppm
V (Vanadium) Max. 2 ppm
Conforms to Ph.Eur./USP Passes test
Ph.Eur. specifications: Max. 0.1 %
Assay (calculated on dried) [Ph.Eur.] 99.0 --> 100.5 %
Identification B [Ph.Eur.] 168 --> 174 °C
Identification C Passes test USP
Appearance of solution Passes test Ph.Eur.
pH (20°C; 5 %) [Ph.Eur.] 10.0 --> 11.5
Related substances [Ph.Eur.] Max. 1.0 %
Cl (Chloride) [Ph.Eur.] Max. 100 ppm
Fe (Iron) [Ph.Eur.] Max. 10 ppm
Loss on drying (105°C) [Ph.Eur.] Max. 0.5 %
Sulphated ash [Ph.Eur.] Max. 0.1 %
USP specifications:
Assay (calculated on dried basis) [USP] 99.0 --> 101.0 %
Identification A Passes test USP
Identification B Passes test USP
Residue on ignition [USP] Max. 0.1 %
Melting range or temperature [USP] 168 --> 172 °C
pH (5 %) [USP] 10.0 --> 11.5
Loss on drying (105°C; 3 h) [USP] Max. 1.0 %

 

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