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White Papers and Detailed Investigations

White Papers and Detailed Investigations

You can learn more about a particular area of chromatography.  We have a range of educational information available for you.

An Intelligent Solution for Hydrophilic Interaction Liquid Chromatography Method Development

Are you interested in learning more about HILIC to see how it could benefit your lab for the separation of hydrophilic neutral and polar compounds?

Analysis of Glycans

Monoclonal Antibodies (mAbs) are a class of compound that present many challenges to the separation scientist. We review the importance of glycan analysis and the approaches that can be employed.

Achieving successful method translations in liquid chromatography

Learn about the theory, principles and key equations that are required for method translation and how to apply them to isocratic and gradient LC methods. Common pitfalls and the Avantor® ACE® Method Translator tool are also reviewed.

Considerations and best practices for mobile phase buffer selection and pH control for LC and LC-MS Method Development

Harness pH as a tool for method development! Review the theory and impact of pH and the associated buffers in this paper.

Determination of nitrosamine impurities in pharmaceutical API's and addressing issues associated with DMF and NDMA co-elution

Nitrosamine impurities are a topic of increasing global concern but the analysis is challenging. Avantor’s R&D team review LC-MS/MS solutions and how to address key issues for regulatory purposes.

Solid core particles: Application to small molecule LC analysis

Looking to increase performance or throughput of your analysis using solid core particles? Discover the theory behind why they offer advantages over fully porous particles and how to apply these to your own analyses.