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Avantor Services provides a wide range of specialized services and digital solutions to help you solve complex challenges.
We’ve built our reputation on consistent, comprehensive mastery of day-to-day operations, allowing lab, clinical, and production environments to focus their high-value resources on core scientific priorities.
As our customers’ needs have evolved, so have our capabilities. We have become experts in scientific operations, improving performance with sophisticated solutions and providing guidance on best practices.
You can select and customize services for peak efficiency, quality, and accelerated innovation.
Get the convenience of our industry-leading expertise, comprehensive product offerings and custom assemblies for complete application workflows
Get your single-use bioprocess manufacturing line up and running quickly. Let us customize your assemblies or select from our wide range of products to build your own. Choose Masterflex single-use custom disposable sterile assemblies and eliminate assembling, sterilizing, and validating with just one call to us. Or select every component to build your own assemblies. Either way, we offer the widest selection of trusted brands in the bioprocess market for tubing, fittings, gaskets, sanitary fittings and clamps and more.
Too much to choose from? Consult with our technical experts to help you get exactly what you need, so you can start reaping the many benefits of single-use systems: reduced cross-contamination risks, lower capital investment, no more cleaning and sterilizing, reduced turnaround times, scale an operation up or down with limited additional investment and so much more.
Bioprocessing applications rely on Masterflex
Masterflex offers the widest selection of trusted brands in the bioprocess market for tubing, fittings, gaskets, sanitary fittings and clamps and more. Too much to choose from? Consult with our technical experts to help you get exactly what you need. Whatever your process needs — filtration, fluid lines, process containment, process control, cell generation, or sampling — you can count on Masterflex to supply the exact component you need to improve your efficiency.
Media Preparation: A vital step in the upstream process
Media prep is a vital step in the upstream process in which the solution for cell culture is prepared. It requires significant time and effort with innovative approaches, including the use of single-use technology, throughout the entire process. Each approach is individually configured based on the manufacturers’ application. Peristaltic pumps play an important role in dosing the exact amounts of process nutrients and other media using high purity, flexible tubing. Peristaltic pumps can also gently recirculate the cells in the solution and protect cell viability.
Fermentation: Growing microorganisms for the biochemical synthesis of organic compounds
Industrial fermentation involves sampling a tank of controlled pH, aeration, agitation and temperature. It requires more preliminary steps than other bioprocess workflows. Common microorganisms used in this process are Chinese hamster ovary cells (CHO), yeast, fungi and bacteria. Masterflex® peristaltic pumps are useful in this workflow and are recommended over diaphragm pumps. Peristaltic pumps provide accurate dosing capabilities and, unlike diaphragm pumps, have an isolated and unconvoluted fluid path. This makes maintenance easy and ensures no product gets stuck in a crevice.
Harvesting: Collection or clarification of product from fermentation
Typical harvest methods include tangential flow filtration (TFF) or centrifugation as a means of concentrating the target compound. In either of these methods, quality and purity are paramount. Wetted materials (any material touching the fluid) must be validated to USP Class VI and sterilized. Peristaltic pumps remain accurate at higher pressures, making them ideal for filtration centric workflows.
Purification: Removal of impurities from the harvest and clarification workflows
Affinity and ion-exchange chromatography are used to remove metals and reaction by-products along with additional methods of filtration. Recently, single-use tube component assemblies have become more prevalent in this workflow as higher throughputs and versatility on the process floor are demanded. The isolated fluid flow path of peristaltic pumps, such as Masterflex® pumps, is critical to this workflow. These pumps mitigate the potential for contamination and reduce the required material validation.
Fill-Finish: Gently transfer sterile product for packaging or lyophilization
This critical process — highly regulated with global regulatory and compliance requirements — transfers the sterile product, now in its most valuable form, to a sterile vial or bottle before it is packaged and distributed or sent to lyophilization (freeze-drying) before packaging. Peristaltic pumps are the top choice because of their ability to provide easy changeovers, reduce cross-contamination and gently pump shear-sensitive fluids, large molecules and live cells. The valuable end product is contained in the tubing, never touching any part of the pump. Our single-use sterilized assemblies, developed specifically for this process, eliminate downtime for cleaning.
